Poly-Prebiotic powder is a unique powdered blend of researched prebiotic fibers and polyphenols to support gastrointestinal, cellular, and immune function by boosting bifidobacteria and microbiome diversity‡

Don't miss out on exclusive discounts and free shipping – they're just a few clicks away!

Primary Benefits

• Supports microbiome integrity and healthy G.I. function‡

• Provides immune system support‡

• Polyphenol and prebiotic combination boosts bifidobacteria and microbiome diversity‡

• Targets Bifidobacteria and Akkermansia muciniphila to support G.I. barrier function‡

• Blend of researched prebiotics and polyphenols

• Pleasant-tasting fruit flavor

• Shelf-stable with low reported G.I. effects

• Part of the PureGI&trade product line

• Made with high-quality vegan ingredients backed by verifiable science

Dietary Considerations

• Gluten Free

• Non-GMO

Product Details

• Prebiotics are nondigestible components of food that act to modulate and support the gut microbiota. Emerging evidence suggests that they may play an even more significant role than probiotics, performing beneficial metabolic, trophic, and protective functions within the gut, leading to overall cellular, immune and metabolic support. Changes to the diet have been shown to alter microflora within just a few days. Restricted diets typically decrease microbiome diversity, while varied and diverse sources of fiber and polyphenols increase microbiome diversity. High-microbiome diversity has been linked to optimal health and resilience. PreticX™ XOS (xylooligosaccharide) and BioEcolians® α-GOS (alpha-glucooligosaccharide) both promote short-chain fatty acid (SCFA) production in the colon and Bifidobacteria in the GI tract. While XOS promotes the SCFA butyrate, a major energy source for the colonocytes, α-GOS promotes propionate to support both glucose homeostasis and satiety.

• Bifidobacterium is the predominant intestinal bacterial genus during the first year of life and is associated with healthy immune development and cytokine balance, both in infants and later in life. In two comparison studies, obese children and children with celiac disease had lower levels of Bididobacteria compared to healthy controls. In a double-blind, randomized, placebo-controlled study, 32 healthy adult subjects were given 1.4 grams or 2.8 grams of PreticX™ XOS for eight weeks. The Bifidobacterium count increased 21% and 17% from baseline at four and eight weeks, respectively. In an in vitro study using clinical isolates from hospital patients, XOS was found to stimulate growth in all 35 Bifidobacterium strains tested. Other studies show XOS supports bowel motility, nutrient metabolism, and emotional wellness. In a randomized, double-blind, placebo-controlled trial involving 25 subjects, supplementation with 2 grams of α-GOS was found to support abdominal comfort by Day 7. Supplementation continued to offer increasing support throughout the 28-day period, including bowel motility and stool consistency.

• A significant increase in B. longum, B. animalis and lactobacilli was also reported. In addition, BioEcolians® supplemented increased secretion in the mucosa of the antimicrobial peptides β-defensins. These molecules moderates adhesion of bacteria to the intestinal wall and supports healthy cytokine balance in the intestine. The health benefits of polyphenols may be due to their effects on the microflora. These compounds are generally not absorbed, but pass through the GI tract, where they are biotransformed to enhance bioavailability and support healthy gut microbial composition. In an animal study involving mice on a high-fat, high-sucrose diet, supplementation with cranberry polyphenols promoted healthy fat metabolism in the liver, insulin sensitivity, and cytokine balance. It was also shown to markedly increased Akkermansia muciniphila. Animal models indicate a role for Akkermansia on gut barrier function, including increased mucus layer thickness and production of occludin, an essential component of tight junctions.

• Research suggests that polyphenols from blueberry and pomegranate support the growth of lactobacilli and bifidobacterium in the colon, as well as cytokine balance in the GI tract. In contrast to many common prebiotics, studies on XOS, α-GOS and polyphenols report very low incidence of gas, bloating or other intestinal side effects.

  • Blend of researched prebiotics and polyphenols with prebiotic effects*

  • Targets Bifidobacteria and Akkermansia muciniphila to support GI barrier function

Suggested Use

• As a dietary supplement, take 1 serving, 1-2 times daily, mixed with a beverage or into food.

Warnings

• If you are pregnant or lactating, have any health condition or are taking any medication, consult your health professional before use.

• Keep out of the reach of children.

• Use only if safety seal is intact. Packaged by weight, not volume. Settling may occur.

• BioEcolians® is a registered trademark of Solabia.

References:

1. A polyphenol-rich cranberry extract protects from diet-induced obesity, insulin resistance and intestinal inflammation in association with increased Akkermansia spp. Population in the gut microbiota of mice—PubMed. (n.d.). Retrieved November 2, 2024, from https://pubmed.ncbi.nlm.nih.gov/25080446/

2. Dietary Habits of 2- to 9-Year-Old American Children Are Associated with Gut Microbiome Composition—PubMed. (n.d.). Retrieved November 2, 2024, from https://pubmed.ncbi.nlm.nih.gov/31668602/

3. Diets naturally rich in polyphenols and/or long-chain n-3 polyunsaturated fatty acids differently affect microbiota composition in high-cardiometabolic-risk individuals—PubMed. (n.d.). Retrieved November 2, 2024, from https://pubmed.ncbi.nlm.nih.gov/32114641/

4. Effects of polyhydroxy compounds on the structure and activity of alpha-chymotrypsin—PubMed. (n.d.). Retrieved November 2, 2024, from https://pubmed.ncbi.nlm.nih.gov/12054616/

5. Fecal Akkermansia muciniphila Is Associated with Body Composition and Microbiota Diversity in Overweight and Obese Women with Breast Cancer Participating in a Presurgical Weight Loss Trial—Journal of the Academy of Nutrition and Dietetics. (n.d.).

6. Finegold, S. M., Li, Z., Summanen, P. H., Downes, J., Thames, G., Corbett, K., Dowd, S., Krak, M., & Heber, D. (2014). Xylooligosaccharide increases bifidobacteria but not lactobacilli in human gut microbiota. Food & Function, 5(3), 436–445. https://doi.org/10.1039/c3fo60348b

7. Microbiome Responses to an Uncontrolled Short-Term Diet Intervention in the Frame of the Citizen Science Project—PubMed. (n.d.). Retrieved November 2, 2024, from https://pubmed.ncbi.nlm.nih.gov/29738477/

8. (PDF) Prebiotic Potential and Chemical Composition of Seven Culinary Spice Extracts: Prebiotic potential of spice extracts…. (n.d.). Retrieved November 2, 2024, from https://www.researchgate.net/publication/318221027_Prebiotic_Potential_and_Chemical_Composition_of_Seven_Culinary_Spice_Extracts_Prebiotic_potential_of_spice_extracts

9. Salivary and fecal microbiota and metabolome of celiac children under gluten-free diet—PubMed. (n.d.). Retrieved November 2, 2024, from https://pubmed.ncbi.nlm.nih.gov/27452636/

10. The Effect of Bioecolians, A Commercial Alpha-Gluco-Oligosacchari. (n.d.). Retrieved November 2, 2024, from https://www.longdom.org/open-access/the-effect-of-bioecolians-a-commercial-alphaglucooligosaccharide-on-bowel-function-in-subjects-with-ibsc-symptoms-61619.html

11. Xylo-oligosaccharide (XOS) in combination with inulin modulates both the intestinal environment and immune status in healthy subjects, while XOS alone only shows prebiotic properties—PubMed. (n.d.). Retrieved November 2, 2024, from https://pubmed.ncbi.nlm.nih.gov/22264499/

12. Xylo-oligosaccharides alone or in synbiotic combination with Bifidobacterium animalis subsp. Lactis induce bifidogenesis and modulate markers of immune function in healthy adults: A double-blind, placebo-controlled, randomised, factorial cross-over study—PubMed. (n.d.). Retrieved November 2, 2024, from https://pubmed.ncbi.nlm.nih.gov/24661576/