Microbiome Labs | MegaSporeBiotic

Written By Jameel Moksa Battle

MegaSporeBiotic™: The Ultimate Spore-Based Probiotic for Gut Health. MegaSporeBiotic™ is a 100% spore-based, broad-spectrum probiotic shown to maintain healthy gut barrier function. This unique all-spore formula effectively RECONDITIONS the gut by promoting microbial diversity and maintaining key health-promoting, commensal gut bacteria. MegaSporeBiotic™ boasts a 5-year shelf-life, does not require refrigeration, and maintains a healthy gut microbiome.*

 

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Primary Benefits

  • Research indicates that Akkermansia nurtures the gut microbiome, optimizes the balance of the gut-mucus layer, and maintains a healthy ecosystem of beneficial bacteria in the gut microbiome.

  • This keystone strain is found in over 1,000+ science publications and is known as the next-generation strain at the forefront of gut health.

Dietary Considerations

  • The ingredients in Akkermansia are GRAS (Generally Recognized As Safe), and customers who take it for general gut health have reported a wide variety of benefits.

Product Details

  • Strain in the product: Akkermansia muciniphila WB-STR-0001

  • AFU Information: 100 million AFUs per capsule.

  • Akkermansia is a next-generation beneficial strain that is essential for gut health.

    • Novel strains
      Pendulum Akkermansia holds a patented strain of Akkermansia muciniphila.  It serves as one of the unique strains discovered through high-resolution DNA sequencing.

    • Targeted function
      Pendulum Akkermansia has been linked to helping with improved gut health.*  Pensulum Akkermansia contains one strain.  Akkermansia muciniphia.

    • Next-generation strain
      Akkermansia is found in 1,000+ science publications and is known as the next-generation strain at the forefront of gut health.

Suggested Use

  • Adults take 1 daily with food or as recommended by your health care professional.

Warnings

  • Adults take 1 daily with food or as recommended by your health care professional.

References:

  1. Campbell, A. W., Sinatra, D., Zhang, Z., & Sinatra, S. T. (2020). Efficacy of Spore Forming Bacilli Supplementation in Patients with Mild to Moderate Elevation of Triglycerides: A 12 week, Randomized, Double-Blind, Placebo Controlled Trial. Integrative Medicine (Encinitas, Calif.), 19(2), 22–27.

  2. Catinean, A., Neag, A. M., Nita, A., Buzea, M., & Buzoianu, A. D. (2019). Bacillus spp. Spores—A Promising Treatment Option for Patients with Irritable Bowel Syndrome. Nutrients, 11(9), 1968. https://doi.org/10.3390/nu11091968

  3. Catinean, A., Neag, M. A., Krishnan, K., Muntean, D. M., Bocsan, C. I., Pop, R. M., Mitre, A. O., Melincovici, C. S., & Buzoianu, A. D. (2020). Probiotic Bacillus Spores Together with Amino Acids and Immunoglobulins Exert Protective Effects on a Rat Model of Ulcerative Colitis. Nutrients, 12(12), 3607. https://doi.org/10.3390/nu12123607

  4. Duysburgh, C., Van Den Abbeele, P., Krishnan, K., Bayne, T. F., & Marzorati, M. (2019). A synbiotic concept containing spore-forming Bacillus strains and a prebiotic fiber blend consistently enhanced metabolic activity by modulation of the gut microbiome in vitro. International Journal of Pharmaceutics: X, 1, 100021. https://doi.org/10.1016/j.ijpx.2019.100021

  5. Marzorati, M., Bubeck, S., Bayne, T., Krishnan, K., & Giusto, M. (2022). Effects of Combined Prebiotic, Probiotic, IgG and Amino Acid Supplementation on the Gut Microbiome Of Patients With Inflammatory Bowel Disease. Future Microbiology, 17(16), 1307–1324. https://doi.org/10.2217/fmb-2022-0066

  6. Marzorati, M., Van Den Abbeele, P., Bubeck, S., Bayne, T., Krishnan, K., & Young, A. (2021). Treatment with a spore-based probiotic containing five strains of Bacillus induced changes in the metabolic activity and community composition of the gut microbiota in a SHIME® model of the human gastrointestinal system. Food Research International, 149, 110676. https://doi.org/10.1016/j.foodres.2021.110676

  7. McFarlin, B. K., Henning, A. L., Bowman, E. M., Gary, M. A., & Carbajal, K. M. (2017). Oral spore-based probiotic supplementation was associated with reduced incidence of post-prandial dietary endotoxin, triglycerides, and disease risk biomarkers. World Journal of Gastrointestinal Pathophysiology, 8(3), 117. https://doi.org/10.4291/wjgp.v8.i3.117

  8. Neag, M. A., Catinean, A., Muntean, D. M., Pop, M. R., Bocsan, C. I., Botan, E. C., & Buzoianu, A. D. (2020). Probiotic Bacillus Spores Protect Against Acetaminophen Induced Acute Liver Injury in Rats. Nutrients, 12(3), 632. https://doi.org/10.3390/nu12030632

  9. Ramezani Kapourchali, F., Glueck, B., Han, Y., Shapiro, D., Fulmer, C. G., & Cresci, G. A. M. (2020). A Spore‐Forming Probiotic Supplement Improves the Intestinal Immune Response and Protects the Intestinal Health During Recurrent Clostridioides difficile Colonization in Mice. Journal of Parenteral and Enteral Nutrition, 44(8), 1428–1438. https://doi.org/10.1002/jpen.1851

  10. Shapiro, D., Kapourchali, F. R., Santilli, A., Han, Y., & Cresci, G. A. M. (2022). Targeting the Gut Microbiota and Host Immunity with a Bacilli-Species Probiotic during Antibiotic Exposure in Mice. Microorganisms, 10(6), 1178. https://doi.org/10.3390/microorganisms10061178

 
Jameel Moksa Battle
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