ChromaDex | Tru Niagen

Written By Jameel Moksa Battle

Our foundational daily serving of 300mg boosts and sustains NAD+ levels to over 50% in most individuals with daily use. Support your cellular energy production and cellular repair with Niagen®, our award-winning, superior NAD+ precursor.

Tru Niagen is one of the most well-researched NAD+-boosting supplements available. Supports resilience against daily stressors and the natural aging process at the cellular level. Increase your NAD+ levels to support heart, brain, muscle, and whole-body health for enhanced vitality and healthy aging.

 

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Primary Benefits

  • Replenishing NAD levels [4, 6, 13, 14]

  • Increasing cellular energy production [14]

  • Promoting healthy cellular metabolism [15-17]

  • Promoting cellular repair [7, 15, 17, 18]

  • Supporting healthy aging [4, 6, 13, 14]

  • Clinically proven to boost nicotinamide adenine dinucleotide (NAD+), which is vital to life as we know it.

Dietary Considerations

  • Vegetarian capsules

  • Gluten-Free

  • Vegan

Product Details

  • Tru Niagen is meant to be taken daily to support increased NAD+ levels. If you're a new user, we recommend starting with 300mg/day, which is clinically proven to increase NAD+ levels by up to 50% in as soon as two weeks and allow your cells to establish a new baseline NAD+ level with continued supplementation over the course of about eight weeks. Please note that everyone's experience will be different and is greatly dependent on your overall health and other factors.

  • Depending on your lifestyle, stressors, and diet, you can further supplement with Tru Niagen by adding an additional capsule.

  • Tru Niagen is safe to consume up to 2,000mg/day.

Suggested Use

  • Serving Size: 1 Vegetarian Capsule

  • Amount Per Serving: 300mg NIAGEN® (nicotinamide riboside chloride)

Warnings

  • Use only if the bottle is sealed. Store tightly sealed in a cool, dry place. If pregnant, consult your health-care practitioner before using this product.

References

  1. Rajman, L., K. Chwalek, and D.A. Sinclair, Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence. Cell Metab, 2018. 27(3): p. 529-547.

  2. Verdin, E., NAD(+) in aging, metabolism, and neurodegeneration. Science, 2015. 350(6265): p. 1208-13.

  3. Yoshino, J., J.A. Baur, and S.I. Imai, NAD(+) Intermediates: The Biology and Therapeutic Potential of NMN and NR. Cell Metab, 2018. 27(3): p. 513-528.

  4. Airhart, S.E., et al., An open-label, non-randomized study of the pharmacokinetics of the nutritional supplement nicotinamide riboside (NR) and its effects on blood NAD+ levels in healthy volunteers. PLoS One, 2017. 12(12): p. e0186459.

  5. Martens, C.R., et al., Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD(+) in healthy middle-aged and older adults. Nat Commun, 2018. 9(1): p. 1286.

  6. Trammell, S.A., et al., Nicotinamide riboside is uniquely and orally bioavailable in mice and humans. Nat Commun, 2016. 7: p. 12948.

  7. Massudi, H., et al., Age-associated changes in oxidative stress and NAD+ metabolism in human tissue. PLoS One, 2012. 7(7): p. e42357.

  8. Zhou, C.C., et al., Hepatic NAD(+) deficiency as a therapeutic target for non-alcoholic fatty liver disease in ageing. Br J Pharmacol, 2016. 173(15): p. 2352-68.

  9. Canto, C., et al., The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity. Cell Metab, 2012. 15(6): p. 838-47.

  10. Gariani, K., et al., Eliciting the mitochondrial unfolded protein response by nicotinamide adenine dinucleotide repletion reverses fatty liver disease in mice. Hepatology, 2016. 63(4): p. 1190-204.

  11. Seyssel, K., et al., Regulation of energy metabolism and mitochondrial function in skeletal muscle during lipid overfeeding in healthy men. J Clin Endocrinol Metab, 2014. 99(7): p. E1254-62.

  12. Wang, S., et al., Nicotinamide riboside attenuates alcohol induced liver injuries via activation of SirT1/PGC-1alpha/mitochondrial biosynthesis pathway. Redox Biol, 2018. 17: p. 89-98.

  13. Dollerup, O.L., et al., A randomized placebo-controlled clinical trial of nicotinamide riboside in obese men: safety, insulin-sensitivity, and lipid-mobilizing effects. Am J Clin Nutr, 2018.

  14. Martens, C.R., Denman, B.A., Mazzo, M.r., Armstrong, M.L., Reisdorph, N., McQueen, M.B., Chonchol, M.B., Seals, D.R., Chronic nicotinamide riboside supplementation is well-tolerated and effectively elevates NAD+ in healthy middle-aged and older adults. 2018, University of Colorado Boulder.

  15. Bieganowski, P. and C. Brenner, Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans. Cell, 2004. 117(4): p. 495-502.

  16. Guest, J., et al., Changes in oxidative damage, inflammation and [NAD(H)] with age in cerebrospinal fluid. PLoS One, 2014. 9(1): p. e85335.

  17. Ratajczak, J., et al., NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells. Nat Commun, 2016. 7: p. 13103.

  18. Zhu, X.H., et al., In vivo NAD assay reveals the intracellular NAD contents and redox state in healthy human brain and their age dependences. Proc Natl Acad Sci U S A, 2015. 112(9): p. 2876-81

 
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